ProTx-III – Ion Channels and Transporters
ProTx-III (µ-TRTX-Tp1a; belongs to NaSpTx family 1) has been isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens at the University of Queensland (Australia). ProTx-III has been described to be a selective inhibitor of Nav1.7 with an IC50 value around 2 nM. The synthetic version of Tp1a produced by Genpabio yields similar results in terms of Nav1.7 inhibition (see Figure 1). Queensland scientists have described that ProTx-III induces no significant changes in the voltage dependence of activation or steady-state inactivation of Nav1.7. ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors. ProTx-III demonstrates analgesic properties in vivo when injected intraplantary in mice prior treatment with OD1, an activator of Nav1.7, which induces spontaneous pain.
Technical specification
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Sequence : | H-DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2 (Cys2-Cys17; Cys9-Cys22; Cys16-Cys29) |
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MW : | 3802.47 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| PTX003-0.1 mg | 0.1 mg | 209€ | 251$ |
| PTX003-0.5 mg | 0.5 mg | 627€ | 753$ |
| PTX003-1 mg | 1 mg | 990€ | 1188$ |
| PTX003-5 x 0.01 mg | 5 x 0.01 mg | 121€ | 146$ |
If you’d like to learn more about this toxin, visit our product page on our Genpabio website—Our sister company specializing in the synthesis of complex toxins.