NMB-1 – Ion Channels and Transporters
NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting mechanically activated currents over rapidly adapting ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 μM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 μM.
Genpabio Biotechnology is pleased to be the first company offering this research tool.
Technical specification
| Sequence : | H-FNWRCCLIPCRRNHKKFFC-OH (Cys5-Cys19; Cys6-Cys10) | |
| MW : | 2467.03 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| NMB001-0.1 mg | 0.1 mg | 149€ | 179$ |
| NMB001-0.5 mg | 0.5 mg | 429€ | 515$ |
| NMB001-1 mg | 1 mg | 605€ | 726$ |
If you’d like to learn more about this toxin, visit our product page on our Genpabio website—Our sister company specializing in the synthesis of complex toxins.