Maurocalcine – Ion Channels and Transporters
Maurocalcine, a component of the venom of Scorpio maurus palmatus, was discovered by Michel De Waard, co-founder of Genpabio. Maurocalcine folds according to an inhibitor cysteine knot. Such as Imperatoxin A, Maurocalcine acts as a high affinity agonist of the type-1 ryanodine receptor expressed in skeletal muscles with an affinity in the 10 nM range. Maurocalcine induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. Maurocalcine has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.
Technical specification
| Sequence : | H-GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR-OH (Cys3-Cys17; Cys10-Cys21; Cys16-Cys32) | |
| MW : | 3858.56 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 07MAU001-0.1 mg | 0.1 mg | 187€ | 225$ |
| 07MAU001-0.5 mg | 0.5 mg | 561€ | 674$ |
| 07MAU001-1 mg | 1 mg | 935€ | 1122$ |
If you’d like to learn more about this toxin, visit our product page on our Genpabio website—Our sister company specializing in the synthesis of complex toxins.