GaTx2 – Ion Channels and Transporters
GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
Technical specification
| Sequence : | H-VSCEDCPDHCSTQKARAKCDNDKCVCEPI-OH (Cys3-Cys19; Cys6-Cys24; ; Cys10-Cys26) | |
| MW : | 3191.25 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 10GTX002-0.1 mg | 0.1 mg | 220€ | 264$ |
| 10GTX002-0.5 mg | 0.5 mg | 715€ | 858$ |
| 10GTX002-1 mg | 1 mg | 1100€ | 1320$ |
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