(Dap22)-ShK – Ion Channels and Transporters
(Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin #08SHK001 (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6 (KCNA6) respectively with a Kd of 11 pM,16 pM, 312 pM and 165 pM. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. The high selectivity of (Dap22)-Shk is achieved thanks to the strong binding between the Dap and His404 / Asp386 residues of Kv1.3 channel. (Dap22)-ShK inhibits T cell proliferation induced by anti-CD3 at subnanomolar concentrations.
Technical specification
| Sequence : | H-RSCIDTIPKSRCTAFQCKHSM(Dap)YRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32) | |
| MW : | 4012.70 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 13SHD001-0.01 mg | 0.01 mg | 55€ | 66$ |
| 13SHD001-1 mg | 1 mg | 198€ | 238$ |
| 13SHD001-5 x 0.01 mg | 5 x 0.01 mg | 165€ | 198$ |
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