BeKm-1 – Ion Channels and Transporters
BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus. BeKm-1 toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1). BeKm-1 inhibits hERG1 channels expressed in HEK-293 cells with an IC50 of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel. BeKm-1 inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC50 value in the range of 10 to 30 nM. BeKm-1 toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur.
Technical specification
| Sequence : | H-RPTDIKCSESYNCFPVCKSRFGKTNGRCVNGFCDCF-OH (Cys7-Cys28; Cys13-Cys33; Cys17-Cys35) | |
| MW : | 4091.70 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 13BEK001-0.1 mg | 0.1 mg | 149€ | 179$ |
| 13BEK001-0.5 mg | 0.5 mg | 429€ | 515$ |
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