ω-Tbo-IT1 – Ion Channels and Transporters
ω-Tbo-IT1 has been isolated from the venom of the Tibellus oblongus spider. ω-Tbo-IT1 is a selective blocker of insects calcium channels. It has been shown that ω-Tbo-IT1 has a potent insect toxicity with LD50 19?μg/g on house fly Musca domestica larvae and LD50 20?μg/g on juvenile Gromphadorhina portentosa cockroaches. Electrophysiological experiments revealed a reversible inhibition of evoked excitatory postsynaptic currents in blow fly Calliphora vicina neuromuscular junctions with an IC50 value 40?±?10?nM.
Technical specification
| Sequence : | H-CASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM-OH (Cys1-Cys21; Cys8-Cys25; Cys20-Cys40) | |
| MW : | 4331.74 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| ITO001-0.1 mg | 0.1 mg | 330€ | 396$ |
| ITO001-0.5 mg | 0.5 mg | 1155€ | 1386$ |
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