μ-conotoxin-CnIIIC – Ion Channels and Transporters
μ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. μ-conotoxin CnIIIC has been described to exhibit a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). μ-conotoxin CnIIIC also appears to block Nav1.2 channels (1 μM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. μ-conotoxin CnIIIC is also described to block the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes and completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM). This peptide is a valuable tools to study Nav1.4 channels.
Technical specification
| Sequence : | pQ-GCCNGPKGCSSKWCRDHARCC-NH2 (Cys3-Cys15; Cys4-Cys21; Cys10-Cys22) | |
| MW : | 2840.88 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| CON021-0.1 mg | 0.1 mg | 149€ | 179$ |
| CON021-0.5 mg | 0.5 mg | 429€ | 515$ |
| CON021-1 mg | 1 mg | 605€ | 726$ |
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