α-conotoxin-IMI – Ion Channels and Transporters
α-conotoxin IMI (alpha-conotoxin IMI) is a conopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM). It has no effect on nAChRs composed of α2/?2, α3/?2, α4/?2, α2/?4, α3/?4, or α4/?4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
Technical specification
| Sequence : | H-GCCSDPRCAWRC-NH2 (Cys2-Cys8 ; Cys3-Cys12) | |
| MW : | 1351.56 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 08CON011-0.5 mg | 0.5 mg | 215€ | 258$ |
| 08CON011-1 mg | 1 mg | 363€ | 436$ |
If you’d like to learn more about this toxin, visit our product page on our Genpabio website—Our sister company specializing in the synthesis of complex toxins.