GsAF-2

GsAF-2 – Ion Channels and Transporters GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, […]

Technical Specifications

Sequence:	`H-YCQKWMWTCDEERKCCEGLVCRLWCKKKIEW-OH (Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25)`
Purity:	> 95% (by HPLC)
Counter-Ion:	TFA Salts
Delivery Format:	Lyophilized

Product Description & Background

GsAF-2 – Ion Channels and Transporters

GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.

Technical specification

	Sequence :	H-YCQKWMWTCDEERKCCEGLVCRLWCKKKIEW-OH (Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25)
	MW :	3201.54 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
12GSF002-0.1 mg	0.1 mg	220€	264$
12GSF002-0.5 mg	0.5 mg	660€	792$
12GSF002-1 mg	1 mg	1045€	1254$

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