α-conotoxin-PeIA – Ion Channels and Transporters
α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 μM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle ¦Á¦¦æÄ AChRs by 1 μM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
Technical specification
| Sequence : | H-GCCSHPACSVNHPELC-NH2 (Cys2-Cys8; Cys3-Cys16) | |
| MW : | 1651.87 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 13CON017-0.1 mg | 0.1 mg | 72€ | 87$ |
| 13CON017-0.5 mg | 0.5 mg | 193€ | 232$ |
| 13CON017-5 x 0.1 mg | 5 x 0.1 mg | 231€ | 278$ |
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