p53-SAH (Stabilized Alpha-Helix)
Cancer Research Peptide
The p53-SAH peptide is a hydrocarbon-stapled α-helical peptide derived from the p53 transactivation domain, designed to stabilize the native p53 helix involved in binding to the regulatory proteins HDM2 and HDMX. p53-SAH is a well-established research tool for investigating p53 regulatory mechanisms and protein–protein interactions controlling tumor suppressor signaling.
Disease Target
Osteosarcoma, colorectal carcinoma, p53 wild type tumors.
Stapling Strategy
Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) enables solid-phase peptide synthesis (SPPS) of SAH-p53-8. During synthesis, Fmoc-(S5)-OH is incorporated at positions 7 (ex-Thr) and 11 (ex-Leu) of the optimized p53 peptide sequence, followed by ruthenium-catalyzed olefin metathesis to form the (CH?)? hydrocarbon staple that locks the α-helix, preferentially disrupts p53-HDMX complexes over HDM2, and reactivates the p53 apoptotic pathway in vitro and in vivo.
Technical specification
| Sequency : | Ac-QSQQTF(S5)NLWRLL(S5)QN-NH? | |
| MW : | 2067.35?? g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB322-1mg | 1 mg | 552 | 663 |
| SB322-5mg | 5 mg | 701 | 841 |
| SB322-10mg | 10 mg | 948 | 1138 |
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.