NYBSP-1 (ACE2)
Viral Entry & Protein–Protein Interaction Research Peptide
NYBSP-1 is a double hydrocarbon-stapled α-helical peptide derived from Helix-1 of the human angiotensin-converting enzyme 2 (ACE2) receptor. This stapled peptide is designed to stabilize the native ACE2 α-helical conformation involved in binding to the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. NYBSP peptides are widely used as research tools to study viral entry mechanisms and protein–protein interactions between viral ligands and host receptors.
Disease Target
Covid 19 SARS COV 2 (block RBD – ACE2 binding).
Stapling Strategy
Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) enables the solid-phase peptide synthesis (SPPS) of NYBSP ACE2-derived stapled peptides. During synthesis, Fmoc-(S5)-OH is incorporated at two i,i+4 positions within the ACE2 helix-1 region, followed by ruthenium-catalyzed ring-closing olefin metathesis to generate two (CH?)? hydrocarbon staple. The resulting double stapled peptide blocks SARS-CoV-2 Spike RBD binding (IC?? ≈ 130 nM) and inhibits pseudovirus infection by >90% at 10 μM.
Technical specification
| Sequency : | Ac-TIEEQAKT(S5)LDK(S5)NHEAEDLFYQ(S5)SLA(S5)WN-NH2 | |
| MW : |
3664.08 g/mol |
|
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB326-1mg | 1 mg | 762 | 915 |
| SB326-5mg | 5 mg | 964 | 1157 |
| SB326-10mg | 10 mg | 1291 | 1550 |
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.