NYAD-1 _HIV-1 Capsid Stapled Peptide
Antiviral Peptides
NYAD-1 is a hydrocarbon-stapled α-helical peptide derived from the HIV-1 capsid assembly inhibitor CAI sequence. The peptide is designed to stabilize the native α-helical conformation required for binding to HIV-1 capsid protein interfaces. Hydrocarbon stapling enhances structural rigidity, protease resistance, and cellular uptake compared to the corresponding linear peptide. NYAD-1 is widely used as a research tool to investigate capsid assembly, viral maturation, and protein–protein interactions involved in HIV-1 replication.
Disease Target
Targets HIV-1 infection (AIDS) by disrupting viral capsid assembly.
Stapling Strategy
NYAD-1 is synthesized by incorporating Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) residues at i, i+4 positions within the CAI-derived sequence during solid-phase peptide synthesis (SPPS). The hydrocarbon staple is generated via ruthenium-catalyzed ring-closing olefin metathesis, forming a covalent constraint that stabilizes the α-helical conformation and enhances structural rigidity.
Technical specification
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Sequency : | Ac-ITF(S5)DLL(S5)YYGKKK-NH₂ |
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MW : | 1780.16 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB327-1mg | 1 mg | 564 | 677 |
| SB327-5mg | 5 mg | 716 | 860 |
| SB327-10mg | 10 mg | 968 | 1162 |
For more information about stapled peptides, please visit our dedicated page.
Explore our Stapled Peptide Catalog products. Click HERE to discover additional reference compounds.
A fluorescent FAM-labeled version of this peptide is available for imaging and uptake studies. Tap the button below to view the FAM-conjugated product.
Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.