[Glp6,Pro9] Substance P (6-11)/Septide – Neuroscience Peptides

Tachykinins are important neuropeptides throughout the nervous system involved in various roles including smooth muscle activity. Substance P is the natural ligand for neurokinin 1 (NK1) tachykinin receptor. Septide was originally identified from the C-terminus substance P and found to be a selective agonist of NK1 tachykinin receptor. Septide is a potent agonist able to stimulate muscle contraction in various models but not all. However, septide consistently lacks a high affinity for the NK1 tachykinin receptor compared to substance P or other applicable agonists. A ‘septide sensitive’ receptor is speculated, or it could be a conformation of NK1 tachykinin receptor. Further work is required to establish septide function and role in the nervous system. Septide is provided here with an N-terminal pyroglutamic acid to aid this investigation as is standardly used within the literature.

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