BIM – Stapled BH3 Peptide
Cancer Research Peptide
BIM apoptotic peptide is derived from the BH3 domain of the pro-apoptotic Bcl-2 family member BIM. As a stabilized α-helical peptide, it is designed to mimic the native BH3 helix and disrupt anti-apoptotic Bcl-2 family protein interactions. By binding to Bcl-2, Bcl-xL, and related survival proteins, this peptide promotes mitochondrial apoptotic signaling.
Disease Target
Primarily used in cancer research targeting malignancies characterized by dysregulated apoptosis, including leukemias, lymphomas, and solid tumors with overexpression of anti-apoptotic Bcl-2 family proteins. By mimicking the BH3 domain of BIM, this peptide reactivates apoptotic signaling in apoptosis-resistant cancer cells.
Stapling Strategy
BIM is synthesized using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2), incorporated at i,i+4 positions within the BH3 sequence during solid-phase peptide synthesis (SPPS). A ruthenium-catalyzed ring-closing olefin metathesis reaction generates the (CH?)? hydrocarbon staple, stabilizing the α-helical conformation and enhancing cellular permeability and proteolytic stability.
Technical specification
| Sequency : |
EIWIAQELR(S5)IGD(S5)FNAYYA-NH2
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| MW : | 2421.75 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB331-1mg | 1 mg | 651 | 781 |
| SB331-5mg | 5 mg | 825 | 990 |
| SB331-10mg | 10 mg | 1109 | 1331 |
For more information about stapled peptides, please visit our dedicated page.
Explore our Stapled Peptide Catalog products. Click HERE to discover additional reference compounds.
A fluorescent FAM-labeled version of this peptide is available for imaging and uptake studies. Tap the button below to view the FAM-conjugated product.
Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.