Alpha-Casozepine

Alpha-Casozepine – Neuroscience Peptides Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site. alpha-CZP […]

Technical Specifications

Sequence:	`H-YLGYLEQLLR-OH`
Purity:	> 95% (by HPLC)
Counter-Ion:	TFA Salts
Delivery Format:	Lyophilized

Product Description & Background

Alpha-Casozepine – Neuroscience Peptides

Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site. alpha-CZP binds with a significantly lower affinity than benzodiazepines. Intraperitoneal administration of Alpha-Casozepine (alpha-CZP) to rodents results in anticonvulsant and sleep-protecting effects. Human administration reduces physiological stress symptoms in stressed and control patients. alpha-CZP modulated neuronal activity in brain regions linked to anxiety regulation in mice.

Technical specification

	Sequence :	H-YLGYLEQLLR-OH
	MW :	1.266.7 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
CRB1001691-0.5 mg	0.5 mg	141€	170$
CRB1001691-1 mg	1 mg	193€	232$