AF12198 – Immunology – Antigens/Epitotes/Pools/Librairies
AF12198 is a selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1) and thus blocks IL-1β signalling. AF12198 can inhibit IL-1-induced IL-8 production by human dermal fibroblasts and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells. AF12198 also blocks IL-1 induction of IL-6 and down regulates IL-6 induction in monkeys. AF12198 does not bind the human type II IL-1 receptor, or the murine type I IL-1 receptor. IL-1 influences a wide range of immune and inflammatory responses. Sustained expression of even low levels of IL-1 can be harmful in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Technical specification
| Sequence : | Ac-FEWTPGWYQJYALPL-NH2, J is L-azetidine-2-carboxylic acid | |
| MW : | 1.895.9 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| CRB1001289-0.5 mg | 0.5 mg | 282€ | 339$ |
| CRB1001289-1 mg | 1 mg | 385€ | 462$ |
| CRB1001289-5 mg | 5 mg | 815€ | 978$ |
| CRB1001289-10 mg | 10 mg | 1111€ | 1334$ |