stRRL
Antimicrobial Peptide
stRRL is a 7–amino acid hydrocarbon‑stapled amphiphilic peptide engineered to enhance structural stability and antimicrobial potency. The hydrocarbon staple enforces a helical conformation, improving resistance to proteolytic degradation and preserving activity in high-salt environments. Despite its ultrashort length, stRRL maintains strong membrane‑disruptive effects against microbial pathogens, making it a compact and robust model for next‑generation antimicrobial design.
Diseases Target
stRRL is designed to act against antibiotic-resistant bacteria that remain hard to treat under physiological (high-salt, serum-rich) conditions. Its short, stapled helical structure enables potent antimicrobial activity and structural stability, making it a promising template for next‑generation anti‑superbug therapeutics.
Stapling Strategy
Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) enables the solid-phase peptide synthesis (SPPS) of the ultrashort stRRL peptide. During assembly, Fmoc-(S5)-OH is incorporated at i,i+4 positions within the RRR core sequence, followed by ruthenium-catalyzed ring-closing olefin metathesis to generate the (CH₂)₄ hydrocarbon staple.
Technical specification
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Sequency : | Ac-L(S5)RRL(S5)R-NH₂ |
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MW : | 1004.27 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB329-1mg | 1 mg | 478 | 573 |
| SB329-5mg | 5 mg | 608 | 730 |
| SB329-10mg | 10 mg | 827 | 992 |
For more information about stapled peptides, please visit our dedicated page.
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.