Palmitoyl Pentapeptide-4 / Matrixyl
Signal Peptide for collagen, fibronectin and extracellular matrix synthesis
Palmitoyl Pentapeptide-4 (Matrixyl®) is the world’s most extensively studied and commercially successful cosmetic signal peptide, introduced by Sederma in 2000. The KTTKS sequence is a naturally occurring procollagen I C-propeptide fragment (matrikine) that signals fibroblasts to synthesize Collagen I, III, and Fibronectin. The palmitoyl group ensures stratum corneum penetration. A rigorous 12-week split-face randomized controlled trial demonstrated significant improvements in wrinkle depth and skin roughness versus vehicle control.
Main characteristics
Palmitoyl Pentapeptide-4‘s matrikine mechanism mirrors the body’s natural collagen synthesis feedback loop: when collagen is processed, the released KTTKS fragment signals fibroblasts to produce more. Matrixyl mimics this endogenous signal exogenously. Multiple independent human studies confirm consistent anti-aging efficacy without the irritation associated with retinol. It is the gold standard reference peptide in cosmetic research and formulation. Produced via SPPS to ≥95% purity (HPLC + MS). Stable at pH 4.5–7.0.
Applications
- Anti-wrinkle serums and creams
- Firming and anti-aging moisturizers
- Premium anti-aging concentrates and ampoules
- Research on matrikine signaling, procollagen processing, and ECM biology
Technical specification
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Sequency : | Pal-KTTKS-OH |
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INCI name | Palmitoyl Pentapeptide-4 |
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MW : | 802.06 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
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CAS number : | 214047-00-4 |
TFA removal service available (acetate or HCl exchange)
Price
| Product | Size | Price € |
Price $ |
| SB372-20mg | 20 mg | 246.27 | 295.53 |
| SB372-50mg | 50 mg | 369.41 | 443.29 |
| SB372-100mg | 100 mg | 492.55 | 591.06 |
| SB372-500mg | 500 mg | 960.47 | 1152.57 |
Custom Cosmetic Peptides Services
If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.
Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.
Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.