PADRE peptide – AKFVAAWTLKAAA

Universal Major Histocompatibility Complex (MHC) epitope for CD4+ T-cell recruitment and activation

SB-PEPTIDE offers PADRE peptide AKFVAAWTLKAAA.

Pan DR-binding epitope (PADRE) is a universal synthetic peptide binding (MHC)-II receptors,of which Human Leukocyte Antigen (HLA)-DR receptors,present on specific immune cells. This epitope activates antigen specific CD4⁺ T-cells,while initiating innate immune response (inflammatory cascade). This feature describes PADRE’s ability to act as a Toll-like receptor (TLR) agonist which explains its use as adjuvant in many immunotherapeutic vaccines. In addition,PADRE was also reported as an alternative to more complex carriers,such as KLH/BSA or OVA,for prophylaxis and therapeutic vaccines to increase vaccines’ effectiveness and enable large-scale production. Thanks to its high affinity for 15 of the 16 most common HLA-DR types,PADRE has been presented as a universal approach to control anti-tumor immunity and it is currently investigated for the treatment of toxoplasmosis in people with HLA-A*03 type. Moreover,its ability to bind HLA-DR receptors,despite their extreme polymorphism in the human population,makes it a tool of choice to study autoreactive T-cell responses.

SB-PEPTIDE offers the biotinylated,the scrambled version,as well as the restricted version of this PADRE peptide. See “Biotin-PADRE peptide” “PADRE scrambled (AAATLWKAAKFVA)” and “Restricted PADRE peptide – ak(Cha)VAAWTLKAAa-Ahx-C” sections to know the prices.

Technical specification

	Sequence : AKFVAAWTLKAAA – Purity : > 95%
	MW : 1347 ,61 g/mol (C65H102N16O15)
	For research use
	Counter-Ion : TFA Salts (see option TFA removal)
	Delivery format : Freeze dried in polypropylene 2mL microtubes
	Other names : Pan HLA DR-binding epitope
	Peptide Solubility Guideline
	Bulk peptide quantities available

Price

References