Hexapeptide-10 / Serilesine
Laminin-5 derived hexapeptide promoting cell adhesion and basement membrane integrity
Hexapeptide-10 (Serilesine®) contains the bioactive SIKVAV sequence derived from Laminin-5, a key basement membrane glycoprotein. The peptide promotes integrin-mediated keratinocyte adhesion and migration along the dermo-epidermal junction, strengthening basement membrane structural support and improving epidermal renewal. By mimicking the cell adhesion domains of laminin, it activates integrins α3β1 and α6β4, supporting epidermal cohesion and long-term skin regeneration.
Main characteristics
Hexapeptide-10 addresses skin aging from the basement membrane perspective, a structural layer that anchors the epidermis to the dermis. By reinforcing integrin-mediated adhesion, it prevents epidermal detachment and improves skin mechanical resistance. Stable in aqueous formulations at pH 5.0–7.5. Compatible with standard serum and cream bases. Produced via SPPS to ≥95% purity (HPLC + MS).
Applications
- Anti-aging serums targeting skin regeneration and structural support
- Wound healing and post-procedure recovery formulations
- Skin strengthening treatments for fragile, thin skin
- Basement membrane reinforcing products
- Research in integrin-mediated cell adhesion and laminin biology
Technical specification
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Sequency : | H-SIKVAV-OH |
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INCI name | Hexapeptide-10 |
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MW : | 615.76 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
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CAS number : | 146439-94-3 |
TFA removal service available (acetate or HCl exchange)
Price
| Product | Size | Price € |
Price $ |
| SB363-20mg | 20 mg | 363.75 | 436.50 |
| SB363-50mg | 50 mg | 545.62 | 654.75 |
| SB363-100mg | 100 mg | 727.49 | 872.99 |
| SB363-500mg | 500 mg | 1418.61 | 1702.34 |
Custom Cosmetic Peptides Services
If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.
Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.
Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.