Sulanemadlin (ALRN-6924)
Cancer Research Peptide
Sulanemadlin (ALRN-6924) is a potent, cell-permeable stapled peptide designed as a dual inhibitor of the MDM2 and MDMX proteins. It disrupts p53–MDM2 and p53–MDMX protein–protein interactions, leading to reactivation of p53 signaling in tumor cells retaining wild-type TP53. In ER-positive cancer cell lines with wild-type TP53 (e.g., MCF-7 and ZR-75-1), ALRN-6924 demonstrates dose-dependent anti-proliferative activity, with reported IC?? values in the low nanomolar range. When combined with chemotherapeutic agents such as paclitaxel or eribulin, ALRN-6924 enhances antitumor efficacy. The combination induces p53 reactivation, cell cycle arrest, apoptosis in vitro, and tumor growth inhibition in vivo. ALRN-6924 is widely used as a reference stapled peptide for studying p53 pathway modulation and dual MDM2/MDMX inhibition.
Disease Target
Primary disease targets include solid tumors and hematological malignancies retaining wild-type TP53, particularly breast cancer, acute myeloid leukemia (AML), lymphomas, and other p53-dependent cancers driven by MDM2/MDMX overexpression.
Stapling Strategy
ALRN-6924 is synthesized using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) and Fmoc-(R)-2-(7-octenyl)alanine (Fmoc-(R8)-OH, CAS: 945212-26-0), incorporated at i,i+4 positions during SPPS. A ruthenium-catalyzed ring-closing olefin metathesis generates the hydrocarbon staple, stabilizing the α-helical structure and enhancing cellular permeability and proteolytic stability.
Technical specification
| Sequency : | Ac-LTF(R8)EYWAQL(S5)AAAAAa-NH? | |
| MW : | 1987.25 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized | |
 |
CAS number : | 1451199-98-6 |
Price
| Product | Size | Price € |
Price $ |
| SB323-1mg | 1 mg | 602 | 722 |
| SB323-5mg | 5 mg | 763 | 916 |
| SB323-10mg | 10 mg | 1029 | 1235 |
For more information about stapled peptides, please visit our dedicated page.
Explore our Stapled Peptide Catalog products. Click HERE to discover additional reference compounds.
Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.