SAHM1
Cancer Signalling Peptides
SAHM1 is a stapled peptide mimetic derived from a dominant-negative form of Mastermind-like (MAML) that disrupts formation of Notch transcriptional complex. It is widely used as a research tool to investigate Notch signaling and allergic airway inflammation in murine models.
Diseases Target
T-cell acute lymphoblastic leukemia (T-ALL), triple-negative breast cancer (TNBC), and allergic airway inflammation including asthma.
Stapling Strategy
Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) enables the solid-phase peptide synthesis (SPPS) of SAHM1. During assembly, Fmoc-(S5)-OH is incorporated at the i,i+4 positions (9,13), followed by ruthenium-catalyzed ring-closing olefin metathesis to generate the (CH?)? hydrocarbon staple.
Technical specification
| Sequency : | Ac-βAla-ERLRRRI(S5)LCR(S5)HHST-NH? | |
| MW : | 2195.60 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized | |
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CAS number: | 2050906-89-1 |
Price
| Product | Size | Price € |
Price $ |
| SB324-1mg | 1 mg | 601 | 722 |
| SB324-5mg | 5 mg | 763 | 916 |
| SB324-10mg | 10 mg | 1029 | 1235 |
For more information about stapled peptides, please visit our dedicated page.
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.