BIM BH3 _ SAHB (Stabilized Alpha-Helix of BCL-2 domains)
Cancer Research Peptide
The BIM BH3 staple peptide is a hydrocarbon-stapled α-helical peptide derived from the BH3 domain of the pro-apoptotic BCL-2 family protein BID. This stapled peptide is designed to mimic the native BH3 α-helix and selectively interact with anti-apoptotic BCL-2 family members. The hydrocarbon stapling strategy enhances α-helical stability, protease resistance, and cellular uptake compared to the corresponding linear peptide. BIM SAHB is widely used as a research tool to study apoptosis regulation and protein–protein interactions involved in cancer biology.
Disease Target
Leukemias, lymphomas, multiple myeloma, and selected solid tumors such as lung carcinoma.
Stapling Strategy
SAHB (BID BH3) is synthesized using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2), incorporated at i,i+4 positions during solid-phase peptide synthesis (SPPS). A ruthenium-catalyzed ring-closing olefin metathesis generates the hydrocarbon staple, stabilizing the α-helical BH3 structure and enhancing proteolytic stability and cellular activity.
Technical specification
| Sequency : | EDIIRNIARHLA(S5)VGD(S5)NleDRSIW | |
| MW : | 2713.1 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB321-1mg | 1 mg | 651 | 781 |
| SB321-5mg | 5mg | 825 | 990 |
| SB321-10mg | 10mg | 1109 | 1331 |
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.