Oligopeptide-10
Antimicrobial peptide for acne-targeting formulations and microbiome skincare
Oligopeptide-10 is a cationic antimicrobial peptide (AMP) that disrupts bacterial cell membranes through electrostatic interactions with the anionic phospholipid bilayers of gram-positive bacteria. Its amphipathic α-helical structure inserts into bacterial membranes causing rapid cell lysis, with selective efficacy against Cutibacterium acnes (formerly P. acnes) without inducing antibiotic resistance. This mechanism makes it a sustainable alternative to conventional antimicrobials in acne-targeting cosmetics.
Main characteristics
Oligopeptide-10 represents the growing category of antimicrobial peptides (AMPs) in cosmetics, a category driven by increasing antibiotic resistance concerns and demand for microbiome formulations. Unlike classical antimicrobials (benzoyl peroxide, triclosan), AMPs target bacterial membranes rather than metabolic pathways, making resistance development extremely unlikely. Stable at pH 4.5–7.0. Produced via SPPS to ≥95% purity (HPLC + MS).
Applications
- Anti-acne serums and spot treatments targeting C. acnes
- Microbiome-balancing oily and combination skin formulations
- Anti-blemish and pore-minimizing products
- Seborrheic scalp treatments
- Research in antimicrobial peptide mechanisms and skin microbiome modulation
Technical specification
| Sequency : | H-FAKALKALLKALKAL-NH2 | |
| INCI name | Oligopeptide-10 | |
| MW : | 1598.07 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized | |
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CAS number : | 466691-40-7 |
TFA removal service available (acetate or HCl exchange)
Price
| Product | Size | Price € |
Price $ |
| SB366-20mg | 20 mg | 329.76 | 395.71 |
| SB366-50mg | 50 mg | 494.64 | 593.56 |
| SB366-100mg | 100 mg | 659.52 | 791.42 |
| SB366-500mg | 500 mg | 1286.06 | 1543.27 |
Custom Cosmetic Peptides Services
If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.
Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.
Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.