Mag(i+4)1,15
Double-Stapled Antimicrobial Peptide
Mag(i+4)1,15 is a double hydrocarbon-stapled variant of the antimicrobial peptide Magainin-2. Double stapling stabilizes the amphipathic α-helix, conferring enhanced proteolytic resistance and antimicrobial activity compared to the linear peptide.
Disease Target
Mag(i+4)1,15 targets multidrug-resistant (MDR) bacterial infections, including Staphylococcus and Pseudomonas species, and its double-stapled design provides maximal protease resistance with low red blood cell (RBC) toxicity while maintaining activity against both Gram-positive and Gram-negative bacteria.
Stapling Strategy
Mag(i+4)1,15 is synthesized using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) and it enables the solid-phase peptide synthesis (SPPS). During assembly, Fmoc-(S5)-OH is incorporated at two i,i+4 positions (1–5 and 15–19), followed by ruthenium-catalyzed ring-closing olefin metathesis to generate two (CH?)? hydrocarbon staples. The dual stapling locks the peptide into a stabilized α-helical conformation, enhancing cell permeability and antimicrobial activity against both Gram-positive and Gram-negative bacteria, while maintaining low cytotoxicity.
Technical specification
| Sequency : | Ac-G(S5)GKF(S5)HSKKKFGKA(S5)VGE(S5)AKK-NH? (dbl staple) | |
| MW : | 2602.17 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB328-1mg | 1 mg | 883 | 1060 |
| SB328-5mg | 5 mg | 1107 | 1329 |
| SB328-10mg | 10 mg | 1612 | 1934 |
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Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.