FAM-Ahx-NYAD-1 (NYAD-2)
Antiviral Peptides
FAM-Ahx-NYAD-1 (NYAD-2) is a FAM-labeled (Ex/Em = 495/520 nm) cell-penetrating α-helical peptide developed as a potential HIV-1 inhibitor. The hydrocarbon staple stabilizes the α-helical conformation and enhances structural rigidity. To preserve these properties, the FAM label is attached via an Ahx spacer (6-aminohexanoic acid, CAS: 60-32-2). This flexible linker reduces steric interference between the fluorophore and the peptide backbone, ensuring optimal binding and accurate cellular imaging.
Disease Target
Targets HIV-1 infection (AIDS) by disrupting viral capsid assembly. This FAM-labeled analog enables cellular uptake and intracellular tracking while retaining inhibitory activity against HIV-1 capsid formation.
Stapling Strategy
FAM-Ahx-NYAD-1 (NYAD-2) is synthesized by incorporating Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2) at the i,i+4 positions within the CAI-derived sequence during solid-phase peptide synthesis (SPPS). The stapled structure is generated via ruthenium-catalyzed ring-closing olefin metathesis, forming a hydrocarbon constraint that stabilizes the α-helical conformation. An N-terminal FAM label (Ex/Em = 495/520 nm) is introduced through an Ahx spacer, using 6-aminohexanoic acid (Ahx, CAS: 60-32-2) as a flexible linker to separate the fluorophore from the peptide backbone, thereby reducing potential steric interference and preserving the peptide’s binding and conformational properties. This design enables fluorescence-based cellular imaging and uptake studies.
Technical specification
| Sequency : | FAM-Ahx-ITF(S5)DLL(S5)YYGP-NH2 | |
| MW : | 1950.23 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized |
Price
| Product | Size | Price € |
Price $ |
| SB333-1mg | 1 mg | 692 | 802 |
| SB333-5mg | 5 mg | 841 | 981 |
| SB333-10mg | 10 mg | 1088 | 1278 |
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An unlabeled version of this peptide is available for applications not requiring fluorescence. Tap the button below to view the non-conjugated product.
Custom Stapled Peptide Services
If your target is not listed, we offer custom stapled peptide design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.