Acetyl Decapeptide-3 / Rejuline
Signal peptide for skin regeneration and ECM stimulation
Acetyl Decapeptide-3 (trade name Rejuline?) is a 10-amino acid acetylated signal peptide that stimulates extracellular matrix (ECM) remodeling and activates the skin’s natural UV-damage response. By promoting fibroblast activity and collagen synthesis, it visibly reduces fine lines and wrinkles while improving overall skin texture. Suitable for anti-aging serums, post-UV repair formulations, and premium skincare actives.
Main characteristics
Acetyl Decapeptide-3 mimics the signaling activity of growth factors, stimulating fibroblast metabolism and ECM production without requiring biological expression systems. Its acetylated N-terminus enhances stability against proteolytic degradation, ensuring a longer active life in cosmetic formulations. Compatible with standard aqueous formulations, emulsions, and serum bases. Produced via solid-phase peptide synthesis (SPPS) to ≥95% purity confirmed by HPLC and MS.
Applications
- Anti-aging serums and face creams targeting fine lines and wrinkles
- Post-UV exposure repair formulations
- ECM-stimulating actives in premium skincare
- Research applications in skin biology and fibroblast activity studies
Technical specification
| Sequency : | Ac-YRSRKYTSWY-NH2 | |
| INCI name | Acetyl Decapeptide-3 | |
| MW : | 1449.71 g/mol | |
| Purity : | > 95% | |
| Counter-Ion : | TFA Salts | |
| Delivery format : | Lyophilized | |
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CAS number : | 935288-50-9 |
TFA removal service available (acetate or HCl exchange)
Price
| Product | Size | Price € |
Price $ |
| SB348-20mg | 20 mg | 288.02 | 345.62 |
| SB348-50mg | 50 mg | 432.02 | 518.43 |
| SB348-100mg | 100 mg | 576.03 | 691.24 |
| SB348-500mg | 500 mg | 1123.26 | 1347.92 |
Custom Cosmetic Peptides Services
If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.
Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.
Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

